AxolHumaniPSC-DerivedMelanocytes(African)displayvisIBLepigmentationtypicalmorphologyofproliferativemelanocytes.ThesecellshaveexpectedMarkerexpressionofhumanprimarymelanocytessuchasthetranscriptionfactorpairedbox3(PAX3)andmicrophthalmiaassociatedtranscriptionfactor(MITF),alongwiththeexpressoftwokeyproteinsrequiredformelaninproductiontyrosinaserelatedprotein1(TYRP1)andpremelanosome17(PMEL17).
HumaniPSC-DerivedMelanocytesarevalidatedforpuritybyflowcytometry(PMEL17)andfunctionality(confirmationoftheactivationofmelaninsynthesis).Axol HumaniPSC-DerivedMelanocytesprovidearelevantreliablemodelsystemperfectforresearchintopigmentationdisordersastheyarecloselyrelatedtoprimarymelanocytes.
| Startingmaterial | Fibroblasts |
| Donorgender | Male |
| Karyotype | Normal |
| Reprogrammingmethod | Episomalvector |
| Shippingconditions | Dryice |
| Storageconditions | Liquidnitrogen |



