AxolHumaniPSC-DerivedMelanocytes(African)displayvisIBLepigmentationtypicalmorphologyofproliferativemelanocytes.ThesecellshaveexpectedMarkerexpressionofhumanprimarymelanocytessuchasthetranscriptionfactorpairedbox3(PAX3)andmicrophthalmiaassociatedtranscriptionfactor(MITF),alongwiththeexpressoftwokeyproteinsrequiredformelaninproductiontyrosinaserelatedprotein1(TYRP1)andpremelanosome17(PMEL17).
HumaniPSC-DerivedMelanocytesarevalidatedforpuritybyflowcytometry(PMEL17)andfunctionality(confirmationoftheactivationofmelaninsynthesis).Axol HumaniPSC-DerivedMelanocytesprovidearelevantreliablemodelsystemperfectforresearchintopigmentationdisordersastheyarecloselyrelatedtoprimarymelanocytes.
Startingmaterial | Fibroblasts |
Donorgender | Male |
Karyotype | Normal |
Reprogrammingmethod | Episomalvector |
Shippingconditions | Dryice |
Storageconditions | Liquidnitrogen |