AxolHumaniPSC-DerivedVentricularCardiomyocytes(1,000,000viablecells)
HumaniPSC-DerivedVentricularCardiomyocytes(1millioncells)
Theinducedpluripotentstemcells(iPSCs)usedtogenerateHumaniPSC-DerivedVentricularCardiomyocytes(male,ax2520)havebeenwellcharacterizedandusedwidelywithintheresearchcommunity.ForiPSCcharacterizationinformationpleasesee‘BaghbaderaniBA,TianX,NeoBH,etal.cGMP-ManufacturedHumanInducedPluripotentStemCellsAreAvailableforPre-clinicalandClinicalApplications.StemCellReports(2015)’.
CD34+cordbloodcellswerereprogrammedusingepisomalvectorsundercurrentgoodmanufacturingpractice(cGMP)conditionstoproduceamasterbankofiPSCs.Anon-GMP,researchgradeworkingbankofiPSCswerecreatedfromthemasterstockofcGMP-gradeiPSCsforresearchstudies(Baghbaderanietal.,2015).AxolhasdifferentiatedthesematchingresearchgradeiPSCsintoventricularcardiomyocytes,assuchtheseHumaniPSC-DerivedVentricularCardiomyocytescanbeusedforpre-clinicalapplications.