HumaniPSC-DerivedNeuralStemCellsthathavebeengeneticallyeditedusingCRISPR-Cas9technologytointroducetheV337Mmutation(GTG>ATG) intheMAPTgene.ThislineisheterozygousfortheV337Mmutationwhere1allelehasthemutationandtheotheralleleiswildtype.Clickontheproductimagestoseethedataandfurtherdetails.
TheV337MmutationinMAPThasbeenimplicatedinfrontotemporaldementiaandmayhavearoleinAlzheimer"sdisease.ThemutationleadstoacceleratedaggregationofMAPT/tauproteinintofilamentstructures (Nacharajuetal.,1999)andmakestheMAPT/tauproteinmoresusceptIBLetohyperphosphorylation (Alonsoetal.,2004).
| Startingmaterial | Dermalfibroblast |
| Donorgender | Female |
| Donorageatsampling | 64yrs |
| Karyotype | Normal |
| Reprogrammingmethod | Episomalvector |
| Inductionmethod | Monolayer&chemicallydefinedmedium |
| Geneticmodification | HeterozygousfortheMAPTV337Mmutation(GTG>ATG) |
| Geneticmodification | Containsapuromycinresistancecassette(intronic) |
| Size | ≥1.5millioncells |
| Kitcomponents | 1vialofNeuralStemCells(≥1.5millioncells)and1bottleofNeuralPlating-XFMedium(30mL) |
| Growthproperties | Adherent |
| Shippingconditions | Dryice |
| Storageconditions | Liquidnitrogen |



